1.
J Chem Phys
; 154(10): 100401, 2021 Mar 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33722022
2.
Ann N Y Acad Sci
; 1115: 221-39, 2007 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17934057
RESUMO
The NF-kappaB signaling network plays an important role in many different compartments of the immune system during immune activation. Using a computational model of the NF-kappaB signaling network involving two negative regulators, IkappaBalpha and A20, we performed sensitivity analyses with three different sampling methods and present a ranking of the kinetic rate variables by the strength of their influence on the NF-kappaB signaling response. We also present a classification of temporal-response profiles of nuclear NF-kappaB concentration into six clusters, which can be regrouped to three biologically relevant clusters. Last, we constructed a reduced network of the IKK-NF-kappaB-IkappaBalpha-A20 signal transduction based on the ranking.